To take a promising drug to market, it costs on average $500 million. Academic research institutions such as UCSF excel in conducting basic research and early stage human clinical trials, however, for cost reasons it is important that promising therapies are picked up by private industry.
Inflammation is a biological process driven by the immune system to help the body react to infection, irritation or other injury -- and help the body to repair itself. Researchers in the UCSF Helen Diller Family Comprehensive Cancer Center have learned that the mast cell, a cell of the immune system, plays an important role in inflammation.
Nearly two-thirds of US adults are overweight – fueling the twin epidemic of obesity and type 2 diabetes in this country. Allison Xu, an Assistant Professor who was trained at Stanford and joined the UCSF Diabetes Center in 2006, is focused on understanding how the central nervous system regulates body weight and glucose levels.
McGraw Hill has just published “Diabetes DeMystified: A Self-Teaching Guide”, written by our very own UCSF physician and clinical researcher, Umesh Masharani, M.D.
Have you or a loved one ever been frustrated by how your diabetes has been managed in a hospital setting? Thanks to a team of clinicians led by Robert Rushakoff, MD and Umesh Masharani, MD, UCSF has tackled this problem head on by putting in place new insulin management systems for patients with diabetes being treated in UCSF hospitals.
A team of researchers including Miguel Ramalho-Santos, Ph.D., a UCSF Fellow and member of the Diabetes Center, have reported that they have improved a technique for genetically reprogramming mouse cells to become embryonic stem cells. By over-expressing a combination of genes in mouse skin cells, the mouse cells begin to lose their adult functions and function like they did in their embryonic state.
Feroz Papa, M.D., Ph.D. was awarded a prestigious New Innovator Award, one of only 29 investigators nationwide who received this award. The NIH created this new award to help stimulate highly innovative research and support promising new investigators.
Longtime Diabetes Center volunteers, Bobbie and Michael Wilsey, approached Diabetes Center Director, Dr. Jeffrey Bluestone, and Diabetes Teaching Center Medical Director, Dr. Martha Nolte, to express interest in supporting UCSF’s diabetes clinical efforts. All parties agreed that the most effective use of their $250,000 gift would be to establish a clinical diabetes fellowship program in the adult clinic.
When Anastasia Mavropoulos, PhD arrived at UCSF from her home in Belgium, she had already achieved an impressive record of success in studying pancreas development. Her animal model of choice in Belgium? The zebrafish – an organism that has been studied extensively in developmental biology because its embryos develop rapidly, progressing from eggs to larvae in under three days.
UCSF can count another young research star among its ranks. Michael McManus, PhD was recently awarded a $1.75 million research grant by the W.M. Keck Foundation. Each year, the foundation supports promising scientists in the country pursuing breakthrough biomedical research. McManus is rapidly becoming an expert in microRNAs - the so called “dark matter” of the genome.
Last week, a lawsuit filed by the American Diabetes Association and four Bay Area families was settled -- just in time for the start of the school year for an estimated 15,000 California kids with diabetes. Under the agreement, the California State Department of Education will require school districts statewide to assist students with their insulin and other related services.
Several Diabetes Center research associates have been doing their own version of passing the baton – or pipette – this summer as they prepare to enter prestigious graduate research or medical school programs, propelling them to careers that got much of their start in the laboratories of the Diabetes Center.
Diabetes Center Associate Director Michael German, M.D., professor in the UCSF Department of Medicine and the Justine K. Schreyer Endowed Chair in Diabetes Research, was named a 2007 JDRF Scholar – the second year in a row that a Diabetes Center researcher has received this award.