Ira Goldfine, M.D.

Professor in Residence
Ira Goldfine, M.D.

My diabetes research concerns the transmembrane signaling mechanisms for the insulin receptor and related receptors. We are carrying out laboratory and clinical studies to understand the cellular defects in insulin action that exist in insulin resistant subjects. We are focusing on two cellular proteins: PC-1/ENPP1, an inhibitor of the insulin receptor; and HMGA1, a nuclear protein that regulates insulin receptor expression. In addition, we are investigating the effects of exercise training, antioxidants, and new anti-diabetic drugs in insulin-resistant subjects. Another project is the preclinical development of small molecule, insulin receptor activators for eventual use diabetic patients. A final area is the development of small molecule inhibitors of the IGF-1 receptor to treat prostate and other cancers.

Selected Publications

Ryan CJ, Harzstark AH, Youngren JF, Rosenberg J, Lin A, Goldfine ID, Kerner JF, Small EJ. A Pilot Dose Escalation Study of the Effects of Nordihydroguaiaretic acid (NDGA) on Hormone Levels and Prostate Specific Antigen in Patients with Relapsed Prostate Cancer. British Journal of Urology International. 101(4):436-9, 2008.
Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR. Design, Synthesis, and Structure−Activity Relationships of Novel Insulin Receptor Tyrosine Kinase Activators. J Med Chem. 51(19):6173-87, 2008.
Eusebio Chiefari, Francesco Paonessa, Sinan Tanyolac, Carmelo Capula, Tommaso Mazza, Michele Forlin, Stefania Iiritano, Alfredo Fusco, Daniela Foti, Ira D. Goldfine, and Antonio Brunetti. Functional Variants of the Gene for the Architectural Transcription Factor HMGA1 are Frequent and Confer a High Risk for Type 2 Diabetes Mellitus. Abstract. ADA 69th Scientific Sessions. 186-0R, 2009.
Ryan CJ, Zavodovskaya M, Youngren JF, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, Goldfine ID. Inhibitory Effects of Nordihydroguaiaretic acid (NDGA) on the IGF-1 Receptor and Androgen Dependent Growth of LAPC-4 Prostate Cancer Cells. The Prostate. 68(11):1232-40, 2008.
Youngren J, Gable K, Peñaranda C, Maddux B, Zavodovskaya M, Lobo M, Campbell M, Goldfine ID. Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. Breast Cancer Research Treatment. 94 (1):37-46, 2005.
Maddux B, Chang Y-N, Accili D, McGuinness OP, Youngren JF, Goldfine ID. Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. Am J Physiol Endocrinol Metab. In Press, 2006.
Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative Stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23:599-622, 2002.
Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittittta L. The Role of Membrane Glycoprotein PC-1/ENPP1 in the Pathogenesis of Insulin Resistance and Related Abnormalities. Endocr. Rev. 29(1):62-75, 2008.
Ira Goldfine, M.D.

Endocrinology/Metabolism
1600 Divisadero St.,
MZ C431, Box 1616
San Francisco, CA 94143-1616

 

(415) 885-7429
(415) 885-3787

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