Gregory Ku, M.D., Ph.D.
My research focus is the pancreatic beta cell – the body’s only source of insulin. Beta cells are critical for nutrient metabolism: type 1 diabetes is caused by the autoimmune destruction of beta cells and type 2 diabetes ensues when beta cells are unable to meet the demands of increased insulin resistance. Both diseases represent great, unmet clinical needs as type 1 diabetics uniformly require exogenous insulin and type 2 diabetics often progress to insulin dependence as well.
Any cure for type 1 diabetes will require the generation replacement beta cells. In type 2 diabetes, the ideal therapeutic will improve beta cell function in the long term. My goal is to understand the basic processes of insulin production and insulin secretion with the hope that understanding the circuitry of the beta cell will help us create replacement beta cells and/or improve the function of existing beta cells. I have used whole genome RNA interference screens and next generation to begin to probe this unique circuitry – my lab is studying novel regulators of insulin production and secretion identified in these screens in cell lines and in mouse models. We are focused on the identification of novel circuits that might be amenable to therapeutic intervention and lead to the next generation of diabetes treatments.
1. Ku GM, Kim H, Vaughn I, Hangauer M, German MS, McManus MT. RNA-seq reveals unique features of the pancreatic beta cell transcriptome. Mol Endocrinol. 2012 Oct;26(10):1783-92. Epub 2012 Aug 21. PMID: 22915829.
2. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 2012 Jan;8(1):e1002449. Epub 2012 Jan 12. PMID: 22253604.