Islet Biology Program

 

The Islet Biology Program includes research related to the development and function of the islet. One primary research focus is the overlapping steps in the progression from stem cells to organized islets. Investigators compare and contrast pancreas development in organisms as varied as flies, zebrafish, mice, and humans. There is a strong emphasis on studies of islet regeneration oriented towards producing islets for transplantation into patients with type 1 and type 2 diabetes. Islet Biology researchers also study islet function ranging from the generation of islet autoantigens predisposing islets to destruction in Type 1 diabetes to the regulation of beta-cell turnover and the progressive decline in beta cell function leading to beta cell failure and Type 2 diabetes.

 

Islet Biology Program Members and Research Activities:

Islet Differentiation and Function

Steinunn Baekkeskov, PhD

Robert Blelloch, MD, PhD

Tejal Desai, PhD

Michael German, MD

Gerold Grodsky, PhD

Matthias Hebrok, PhD

Lily Jan, PhD

Feroz Papa, MD, PhD

Michael McManus, PhD

Miguel Ramalho-Santos, PhD, MSc

Jeremy Reiter, MD, PhD

Steven Rosen, PhD

John Rubenstein, MD, PhD

Eric Rulifson, PhD

Didier Stainier, PhD

 

CENTER MEMBERS ARE REMINDED TO ACKNOWLEDGE DRC CENTER GRANT (P30 DK063720) CONTRIBUTIONS WITH ‘THIS RESEARCH WAS SUPPORTED BY GRANTS X, Y FROM NIH P30 DK063720'.