Stephen Rosenthal, M.D.

Contact Info Stephen Rosenthal, MD Peds Endocrinology Box 0434, S 677 513 Parnassus Ave. San Francisco, CA 94143 Tel: (415) 476-2266 Fax: (415) 476-4009 Email: smr@itsa.ucsf.edu

Professor in Residence

I am a Board Certified Pediatric Endocrinologist; have been at UCSF since 1979 (fellowship); joined the faculty in 1983, and have been Professor of Pediatrics since 1998. I am one of two founding faculty members in the Pediatric Diabetes Program at UCSF, and have been working in Diabetes since the inception of our Peidatric Diabetes Program approximately 10 years ago.
I am Principal Investigator on a variety of clinically related studies in Pediatric/Adolescent Type 1 Diabetes, and, in particular, am co-Investigator in the NIH-sponsored TrialNet program.

Overview of Clinical Responsibilities:

I am one ofthe faculty in the Pediatric Diabetes Program, where I see patients and train postdoctoral fellows, pediatric residents, and medical students in both the in-patient and out-patient settings.

Silverman LA, Cheng Z-Q, Hsiao D, Rosenthal SM: Skeletal muscle cell-derived insulin-like growth factor (IGF) binding proteins inhibit IGF-I induced myogenesis in rat L6E9 cells. Endocrinology 136:720-726, 1995.

Hernandez-Sanchez C, Werner H, Roberts Jr C, Woo EJ, Hum D, Rosenthal SM, LeRoith D: Differential regulation of the IGF-I receptor gene by IGF-I and basic fibroblast growth factor. J Biol Chem 272:4663-4670, 1997.

Rosenthal SM: IGFs and Skeletal Muscle, In: The IGF System: Molecular Biology, Physiology and Clinical Applications, Rosenfeld RG, Roberts Jr CT (eds). Humana Press, Totowa, NJ. pp 497-516, 1999.

Cheng Z-Q, Adi S, Hsiao D, Woo EJ, Filvaroff EH, Gustafson TA, Rosenthal SM: Functional inactivation of the insulin-like growth factor-I receptor delays differentiation in skeletal muscle cells. J Endocrinol 167:175 - 182, 2000.

Adi S, Cheng Z-Q, Zhang P-L, Wu NY, Mellon SH, Rosenthal SM: Opposing early inhibitory and late stimulatory effects of insulin-like growth factor-I on myogenin gene trancription. J Cell Biochem 78:617-626, 2000.

Adi S, Wu NY, Rosenthal SM: Growth factor activation of Akt and p70S6K is differentially inhibited by LY294002 and wortmannin. Endocrinology 142:498-501, 2001.

Adi S, Bin-Abbas B, Wu NY, Rosenthal SM: Early stimulation and late inhibition of Erk1/2 phosphorylation by IGF-1:A potential mechanism mediating the switch in IGF-I action on skeletal muscle cell differentiatio. Endocrinology 143:511-516; 2002.